in spite of 、despite of 和 despite 都可以表示“不管…,尽管…”的意思,in spite of和despite of是介词短语,后面跟名词、介词、动名词；而despite是个连词,后面跟的是句子.
The boys went for a walk despite of the rain.
尽管下雨,孩子们还是去散步.
They kept going in spite of their fears.
他们不顾害怕继续前进
Despite what others say,I think he's a very nice chap.
不管别人怎麽说,我仍认为他这个人很好.