screw up 稍微文明点的翻译为：搞砸了!
screw the permit 意为：把个（允许的）机会搞砸了!
screw 作脏话用时,则意指男女之间的那码子事了.
screw up
To muster or summon up:
召集或号召：
screwed up my courage.
鼓起我的勇气
Slang To make a mess of (an undertaking).
【俚语】 把（事业）弄糟
Slang To injure; damage:
【俚语】 伤害；破坏：
Lifting those boxes really screwed up my back.
抬这些箱确实令我的背部受到损伤
Slang To make neurotic or anxious.
【俚语】 使心情烦乱或紧张