这是一个宾语从句,宾语从句的语序是：主句+引导词+陈述句的语序（主谓结构）
所以正确答案是：Do you know what the news is?
至于你的追问：
你记住：What's wrong with you?
What's the matter with you?
What's the trouble with you?
他们本身就是陈述句的语序,不必变化.