(0.25)^2005*(-4)^2004-0.125^2004*(-8)^2005
=0.25^2004*4^2004*0.25+0.125^2004*8^2004*8
=(0.25*4)^2004*0.25+(0.125*8)^2004*8
=0.25+8
=8.25.