你怎么啦?/你有什么麻烦/烦恼事啦?英语中有三种常见表达：
What's 【wrong】 with you?
=What's 【the matter】 with you?
=What's 【the trouble】 with you?
当然,口语中还可以说：
What's biting you?
=What's eating you?
也就是说,这几个用法一般可以互换,意义和用法也没有多大区分.
祝你学习进步,时时开心!O(∩_∩)O~~