A=9.876543×3.456789=9.876543×(3.456788+0.000001)=9.876543×3.456788+9.876543×0.000001,
B=9.876544×3.456788=(9.876543+0.000001)×3.456788=9.876543×3.456788+3.456788×0.000001,
因为9.876543×3.456788+9.876543×0.000001>9.876543×3.456788+3.456788×0.000001,
所以A>B;
故答案为:>.