be made by+人,be made with+工具.
Bikes are made with machines by workers.
句意是：“自行车是【由工人们】【用机器】生产的”.be made by 后可以接工具麽？be made by 后一般不接工具，如果接【机器】，我们可以把【机器】看做是【操作者】，你说是吗？