p的2次方q+2pq-【-(pq+2pq的2次方-4p的2次方q)】+p的2次方q
=p²q+2pq-【-(pq+2pq²-4p²q)】+p²q
=p²q+2pq+pq+2pq²-4p²q+p²q
=-2p²q+3pq+2pq²
=pq(-2p+3+2q)
=-4*(4+3+4)
=-44