断句是关键：
General matters (on subjects that you know) [that interest the person(you are talking to)] are acceptable.
结构分析：on subjects that you know是复合介词短语作定语,其中that you know是subjects的定语从句.that interest the person you are talking to是定语从句,修饰General matters,其中you are talking to又是the person的定语从句.
所以句子翻译成：
关于你知道的主题,能让跟你谈话的人感兴趣的,可以接受.
例如：汽车,电影明星,等等.