1.what's wrong with you?
2,what can you see?
3,where are you going on your holiday?
4.how does she look like?第一个还可以怎么说？用小学六年级学的内容是啊。医生问病人的啊。。。。你怎么了？我嗓子疼，鼻子也不舒服啊。所以这个语境应该是病人去看耳鼻喉科的。。。。应该是what is the matter吧？一样的。