1.have a problem with：...方面有问题或困难;在某方面有问题
2.have a problem doing：做…不容易,做……有困难；做…不轻易,做……有困难；做…不,做……有困难
eg.The company has problem in servicing its debt.该公司在支付债息方面有问题.
Some products on the market do have problem with distortions in the low-frequency range.市场上有些配备数字信号处理器的产品的确在低频范围内存在失真问题.
You need to turn to a doctor if you have problem to fall asleep.
如果你有失眠问题(难以入睡),还应找个睡眠专家(有这种专家吗?）.
You shouldn't have problem to do this.对此你应该没有什么问题吧.