what is wrong with you?用于一般现在时
意思是：你怎么了?
what was wrong with you?用于一般过去时
指的是：（过去）你怎么了?
例如：
What was wrong with you yesterday.
你昨天怎么了?You are late.What is /was the matter?I didn't get up until eight .was 还是is谢谢！这显然是面对面的对话，用一般现在时就可以了。You are late .What is the matter?你迟到了。怎么了？