1Do you know what is wrong with him? 第一句里的what是主语,因此不用更改句式,直接跟上谓语is就可以了.2Do you know what his address is ? 第二句里的what是宾语,“his address is what?（他的地址是什么?）...恩。。有点道理哈v-v。。那what当主语的例子还有没有尼？Do you know what makes him so excited?Do you know what is the matter?Do you know what has happened?Do you know what your trouble / your problem is?最后一句不是吧。。最后一句是给你对比看一下的。哦·~~~~嗯嗯谢谢这样解释就通了。请采纳吧。谢谢！