能.
that可以引导同位语从句和定语从句.which可以引导定语从句.
例：
The reason that he was too young is not convincing enough.
这个他太年轻的理由不够有说服力.（同位语从句,解释说明是什么样的reason）
It may be the reason that/which caused the buildings damaged like this.
它也许就是导致建筑物损毁成这样的原因.（定语从句,修饰reason）