0.25的2009次方乘以4的2010次方—8的100次方乘以0.5的300次方
=0.25^2009×4^2009×4-（2^3)^100×0.5^300
=（0.25×4)^2009×4-2^300×0.5^300
=1^2009×4-（2×0.5)^300
=4-1
=3