1^2-2^2+3^2-4^2+5^2-6^2+……+99^2-100^2
=(1+2)(1-2)+(3+4)(3-4)+.+(99+100)(99-100)
=-(1+2)-(3+4)-.-(99+100)
=-(1+2+3+4+...+99+100)
=-5050